1-Aminopiperidine → HCID 58999049, compound

Reaction equation

C[O:2][C:3]([C:5]1[C:9]([CH3:10])=[C:8]([C:11]2[CH:16]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:14]=[C:13]([C:21]([F:24])([F:23])[F:22])[CH:12]=2)[N:7]([CH2:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[C:6]=1[CH3:32])=O.[N:33]1([NH2:39])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1>>[N:33]1([NH:39][C:3]([C:5]2[C:9]([CH3:10])=[C:8]([C:11]3[CH:12]=[C:13]([C:21]([F:23])([F:24])[F:22])[CH:14]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:16]=3)[N:7]([CH2:25][CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]3)[C:6]=2[CH3:32])=[O:2])[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]1

Participants

Reactant 2

HCID 166581-Aminopiperidine

HCID 86594074HCID 86594074, compound

Product 1

HCID 58999049HCID 58999049, compound

Procedure

The title compound was synthesized in analogy to example 203, from 5-(3,5-bis-trifluoromethyl-phenyl)-1-cyclohexylmethyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid methyl ester and 1-piperidinamine as R1R2NH, MS (ISP) 530.4 (M+H)+.

Sources & evidence

ORD record: ord-1de4b846e582460c90b405026275a757
Source dataset: uspto-grants-2009_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07579369B2

Reaction notes

Loading…