HCID 23047191, compound → Isopropyl 6-chlorohexanoate
Reaction equation
Cl[CH:2]([CH3:12])[CH2:3][CH2:4][CH2:5][C:6]([O:8][CH:9]([CH3:11])[CH3:10])=[O:7].[Cl:13]C(CCC)CC(OC(C)C)=O>CO>[Cl:13][CH2:12][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH:9]([CH3:11])[CH3:10])=[O:7]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 10.5 gm (0.03 mol) of diamine 15, 6.2 gm (0.03 mol) of isopropyl 5-chlorohexanoate, and 10.0 gm of MeOH was charged to the flask and heated to reflux. After 90 hours, 1.0 gm (5 mmol) of isopropyl 3-chlorohexanoate was added to the mixture. At least 5% amine was present after refluxing 6 hours and the heating was stopped. The crude product was removed of volatiles by rotary evaporation and washed until all of the residue was removed leaving 15 gm (94%) of Quat 7.
Workup
- temperatureheated to reflux
- temperatureafter refluxing 6 hours
- customThe crude product was removed of volatiles by rotary evaporation
- washwashed until all of the residue
- customwas removed
- customleaving 15 gm (94%) of Quat 7
Sources & evidence
- ORD record
- ord-1c3c2fe4a16842cc856e5f1890852da5
- Source dataset
- uspto-grants-1990_06
- Patent number
- US04933327
Reaction notes
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