5-(2-Chloroacetyl)-1,3-dihydro-3-methyl-2H-indol-2-one → HCID 15111515, compound
Reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH:8]2[CH3:15])=O.[C:16]([O:20]C)(=[S:19])[NH:17][NH2:18]>C(#N)C>[O:20]=[C:16]1[NH:17][N:18]=[C:3]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][C:9](=[O:14])[CH:8]3[CH3:15])[CH2:2][S:19]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.0 g 5-(2-chloroacetyl)-1,3-dihydro-3-methyl-2H-indol-2-one, 0.37 g O-methyl thiocarbazate, and 20 ml acetonitrile were refluxed for 2 hrs. The precipitate was isolated by filtration and washed with hot acetonitrile to yield a yellowish powder, 450 mg.
Workup
- customThe precipitate was isolated by filtration
- washwashed with hot acetonitrile
- customto yield a yellowish powder, 450 mg
Sources & evidence
- ORD record
- ord-3e043bc9bf1745018843c558e1c8407d
- Source dataset
- uspto-grants-1990_06
- Patent number
- US04933336
Reaction notes
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