Ethyl bromopyruvate → Ethyl 2-(cyclohexylamino)-1,3-thiazole-4-carboxylate

HRID 2107284

Reaction equation

HRID 2107284 reaction equation
[CH:1]1([NH:7][C:8]([NH2:10])=[S:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:12][C:13](=O)[C:14]([O:16][CH2:17][CH3:18])=[O:15]>C(O)C>[CH:1]1([NH:7][C:8]2[S:9][CH:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 66144Ethyl bromopyruvateHCID 1471603Cyclohexylthiourea

Product 1

HCID 15053542Ethyl 2-(cyclohexylamino)-1,3-thiazole-4-carboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction described in Preparation 42 was repeated, but using 17 g of cyclohexylthiourea, 22 g of ethyl bromopyruvate and 200 ml of ethanol, giving the title compound as a yellow oil.

Workup

  1. customThe reaction described in Preparation 42

Sources & evidence

ORD record
ord-6eb112148f5f445fa45f6d001bb24714
Source dataset
uspto-grants-1990_06
Patent number
US04933355

Linked notes

Loading…