Leu-phe → L-Phenylalanyl-L-leucine

Reaction equation

[NH:1]1[C:18](=[O:19])[C@H:10]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[NH:9][C:7](=[O:8])[C@@H:2]1[CH2:3][CH:4]([CH3:6])[CH3:5].N[C@H](C(N[C@H](C(O)=O)CC1C=CC=CC=1)=[O:27])CC(C)C>>[NH2:9][C@H:10]([C:18]([NH:1][C@H:2]([C:7]([OH:27])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

Reactant 2

HCID 6992310Leu-phe

HCID 7076347cyclo(L-leucyl-L-phenylalanyl)

Product 1

HCID 76808L-Phenylalanyl-L-leucine

Procedure

As a result, it was confirmed that 6.8 mg/l cyclo(L-Leu-L-Phe), 28.7 mg/l L-Leu-L-Phe and 18.5 mg/l L-Phe-L-Leu were formed. No cyclodipeptide or dipeptide was detected in the reaction-mixture when without ATP incubated in the same manner.

Sources & evidence

ORD record: ord-6bbb7f8945b94b3cb218e810ad20e93b
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07514243B2

Reaction notes

Loading…