Benzylamine → HCID 68872594, compound

Reaction equation

[F:1][C:2]([F:15])([CH2:9][C:10]([O:12]CC)=O)[CH2:3][C:4]([O:6]CC)=O.[CH2:16]([NH2:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([N:23]1[C:4](=[O:6])[CH2:3][C:2]([F:1])([F:15])[CH2:9][C:10]1=[O:12])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 12696177Diethyl 3,3-difluoropentanedioate

Product 1

HCID 68872594HCID 68872594, compound

Procedure

React an 8.1 mmol portion of the product of Example 14 with benzylamine using the general procedure set forth in Example 8, and purify by silica gel chromatography using ethyl acetate/hexane as eluant to yield the title compound.

Workup

custompurify by silica gel chromatography

Sources & evidence

ORD record: ord-9b21c2ac84da40db9f19bae0bec19d6a
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07514068B2

Reaction notes

Loading…