3-Bromo-4-methylpyridine → 3-Ethynyl-4-methylpyridine

HRID 2109184Notes

Reaction equation

HRID 2109184 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8].N[C:10]1N=CC(C2N=NN(C3C=C(C=CC=3C)C(NC3C=C(C(C)(C)C)C=C(NS(C)(=O)=O)C=3OC)=O)C=2)=C[CH:11]=1>>[C:10]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH3:8])#[CH:11]

Participants

3

Reactant 2

HCID 8176303-Bromo-4-methylpyridineHCID 210970953-[4-(6-amino-pyridin-3-yl)-[1,2,3]triazol-1-yl]-N-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-4-methyl-benzamide

Product 1

HCID 219548323-Ethynyl-4-methylpyridine

Procedure

3-Ethynyl-4-methyl-pyridine was prepared from 3-bromo-4-methyl-pyridine in the same manner as 2-amino-3-ethynyl pyridine (Example 15).

Sources & evidence

ORD record
ord-efe6581502f84c8389813ae641a57e1a
Source dataset
uspto-grants-2009_04
Patent number
US07514458B2

Reaction notes

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