Ethyl isobutyrylacetate → 1-Cyclopropyl-5-isopropyl-1H-pyrazole-4-carbaldehyde

HRID 2109246

Reaction equation

CC(C)C(=O)CC(OCC)=O.Cl.C1(NN)CC1.[CH:18]1([C:21]2[N:25]([CH:26]([CH3:28])[CH3:27])[N:24]=[CH:23][C:22]=2[CH:29]=[O:30])[CH2:20][CH2:19]1>>[CH:26]1([N:25]2[C:21]([CH:18]([CH3:19])[CH3:20])=[C:22]([CH:29]=[O:30])[CH:23]=[N:24]2)[CH2:27][CH2:28]1

Participants

Reactant 3

HCID 81583Ethyl isobutyrylacetate

HCID 19594967Cyclopropylhydrazine--hydrogen chloride (1/1)

HCID 196201355-cyclopropyl-1-(propan-2-yl)-1H-pyrazole-4-carbaldehyde

Product 1

HCID 210972411-Cyclopropyl-5-isopropyl-1H-pyrazole-4-carbaldehyde

Procedure

1-Cyclopropyl-5-isopropyl-1H-pyrazole-4-carbaldehyde was prepared from ethyl 4-methyl-3-oxopentanoate and cyclopropyl hydrazine hydrochloride in the same manner as 5-cyclopropyl-1-isopropyl-1H-pyrazole-4-carbaldehyde (Example 49).

Sources & evidence

ORD record: ord-90a103d0120e4db49c452f647a453c8b
Source dataset: uspto-grants-2009_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07514458B2

Linked notes

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