HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile → (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile | HCID 11031276 | — |
| Reactant | 2-Tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate | HCID 23149698 | — |
| Product | (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile | HCID 59383148 | 67.8% |
Reaction Steps
Using 2-tetrahydropyranyl 4-aminobicyclo[2,2,2]octane-1-carboxylate (90.0 mg) and (2S)-1-(2-bromoacetyl)pyrrolidine-2-carbonitrile (70.0 mg), the same procedure was followed as in Example 1 to obtain (2S)-1-[[N-[4-(2-tetrahydropyranyl)oxycarbonylbicyclo[2,2,2]oct-1-yl]amino]acetyl]pyrrolidine-2-carbonitrile (85.2 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07514571B2 |
| Source dataset | uspto-grants-2009_04 |
| ORD ID | ord-912ecc7e0af444399c58d71fd99c88ec |
| Source note | uspto-grants-2009_04 |