HCID 57637127, compound → 5-(1-Methylethyl)-2-oxazoleethanamine
Reaction equation
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]1[O:14][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:16][N:17]=1)C1C=CC=CC=1>CO.[Pd]>[CH:18]([C:15]1[O:14][C:13]([CH2:12][CH2:11][NH2:10])=[N:17][CH:16]=1)([CH3:20])[CH3:19]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
6.50 g (22.54 mmol) benzyl[2-(5-isopropyl-oxazol-2-yl)-ethyl]-carbamate are placed in 130 ml of methanol, 3.50 g palladium/charcoal 10% are added, then the mixture is hydrogenated for 5 hours at ambient temperature under a pressure of 14 psi. Then the catalyst is removed by suction filtering, the solution is evaporated down. The residue is extracted with dichloromethane and potassium carbonate solution, the organic phase is dried and evaporated to dryness.
Workup
- customThen the catalyst is removed by suction
- filtrationfiltering
- customthe solution is evaporated down
- extractionThe residue is extracted with dichloromethane and potassium carbonate solution
- customthe organic phase is dried
- customevaporated to dryness
Sources & evidence
- ORD record
- ord-20087eebbdda48429532c38e53e5bb2d
- Source dataset
- uspto-grants-2009_04
- Patent number
- US07517995B2
Reaction notes
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