3-Iodophthalic acid → 3-Iodophthalic anhydride

HRID 21111

Reaction equation

HRID 21111 reaction equation
[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=O)[C:3]=1[C:11]([OH:13])=[O:12]>C(O)(=O)C>[I:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]2[C:5]([O:13][C:11](=[O:12])[C:3]=12)=[O:7]

Participants

3

Reactant 1

HCID 2382313-Iodophthalic acid

Product 1

HCID 2820713-Iodophthalic anhydrideYield 96%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
145 °C

Procedure

3-Iodophthalic acid (4.00 g, 13.7 mmol) was dissolved in anhydrous acetic acid, and the solution was stirred at 145° C. for 1 hour. The solvent of the reaction mixture was evaporated under reduced pressure and the residue was purified by slurry using diisopropylether to obtain 3-iodophthalic acid anhydride (3.6 g, yield 96%).

Workup

  1. customThe solvent of the reaction mixture was evaporated under reduced pressure
  2. customthe residue was purified by slurry

Sources & evidence

ORD record
ord-2fc0ada1147d4bd8ade7960d2b1c0711
Source dataset
uspto-grants-2010_06
Patent number
US07745641B2

Linked notes

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