Bromine → 5,6-Dimethyl-2-benzofuran-1,3-dione
Reaction equation
[CH3:1][C:2]1[CH2:3][CH:4]2[C:8](=[O:9])[O:7][C:6](=[O:10])[CH:5]2[CH2:11][C:12]=1[CH3:13].BrBr>C(O)(=O)C>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[O:9])[O:7][C:6](=[O:10])[C:5]2=[CH:11][C:12]=1[CH3:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of above-mentioned (a) (9.5 g, 53 mmol) in acetic acid (28 ml) was added dropwise a solution of bromine (6.1 ml, 0.12 mol) in acetic acid (28 ml) at 115° C. over a period of 45 minutes, and heated under reflux for 1 hr. The reaction solution was left overnight, and the precipitated crystals were collected by filtration, washed with diethyl ether, followed by drying to give 3.5 g of the title compound.
Workup
- temperatureheated
- temperatureunder reflux for 1 hr
- filtrationthe precipitated crystals were collected by filtration
- washwashed with diethyl ether
- customby drying
Sources & evidence
- ORD record
- ord-775a5915e0134962b64571b7a3ad06c5
- Source dataset
- uspto-grants-2009_04
- Patent number
- US07521451B2
Reaction notes
Loading…