Sodium Methoxide → 2-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethanol

HRID 2112388Notes

Reaction equation

HRID 2112388 reaction equation
[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([CH2:10][O:11][CH2:12][CH2:13][O:14]C(=O)C)[CH:2]=1.C[O-].[Na+]>CO>[N:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]([CH2:10][O:11][CH2:12][CH2:13][OH:14])[CH:2]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 68879998acetic acid 2-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethyl ester

Product 1

HCID 144640472-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethanolYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.79 g (3.36 mmol) acetic acid 2-(3H-imidazo[4,5-b]pyridin-3-ylmethoxy)-ethyl ester were dissolved in 10 ml methanol and 10 mg (1.85 mmol) sodium methoxide were added. The mixture was stirred at room temperature for 3 hours. The orange mixture was concentrated in vacuo to afford 0.64 g (99%) of crude product. MS (EI): 193.2, 163.2, 148.2, 133.2.

Workup

  1. concentrationThe orange mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-6a882374f2714fc8a71d2ed4c286d4ab
Source dataset
uspto-grants-2009_04
Patent number
US07524823B2

Reaction notes

Loading…