3-(Methoxymethyl)benzeneboronic acid → 3-(3'-Methoxymethyl-biphenyl-4-yloxymethyl)-benzoic acid

HRID 2113013

Reaction equation

HRID 2113013 reaction equation
C[O:2][C:3](=[O:19])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15](I)=[CH:14][CH:13]=2)[CH:5]=1.[CH3:20][O:21][CH2:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][CH:28]=1>>[CH3:20][O:21][CH2:22][C:23]1[CH:28]=[C:27]([C:15]2[CH:16]=[CH:17][C:12]([O:11][CH2:10][C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([OH:2])=[O:19])=[CH:13][CH:14]=2)[CH:26]=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 38258553-(Methoxymethyl)benzeneboronic acidHCID 57643351Methyl 3-((4-iodophenoxy)methyl)benzoate2×

Product 1

HCID 115810623-(3'-Methoxymethyl-biphenyl-4-yloxymethyl)-benzoic acid

Procedure

3-(3′-Methoxymethyl-biphenyl-4-yloxymethyl)-benzoic acid was prepared using the procedure described above for the preparation of Example 12 from 3-(4-iodo -phenoxymethyl)-benzoic acid methyl ester (of Intermediate 1) and 3-methoxymethylphenylboronic acid (available from Digital Specialty Chemicals, Inc., Dublin, N.H.). Mass spectrum MH+=349.

Sources & evidence

ORD record
ord-63867813441b41ef9a4c0340fb6e4768
Source dataset
uspto-grants-2009_04
Patent number
US07524870B2

Linked notes

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