1-(Quinolin-4-yl)ethanol → 1-(Quinolin-4-yl)ethan-1-one
Reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:13])[CH3:12])=[CH:3][CH:2]=1>ClCCl.[O-2].[Mn+2]>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11](=[O:13])[CH3:12])=[CH:3][CH:2]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To the mixture of manganese oxide (8.69 g, 100 mmol, Aldrich) in dichloromethane (80 mL) was added 1-quinolin4-yl-ethanol (1.73 g, 10 mmol). The reaction mixture was refluxed for overnight and then cooled to room temperature. The solid was filtered out through Celite pad. The organic solution dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow solid in 100% yield (1.71 g, 10.0 mmol).
Workup
- temperatureThe reaction mixture was refluxed for overnight
- filtrationThe solid was filtered out through Celite pad
- dry with materialThe organic solution dried over anhydrous magnesium sulfate
- concentrationconcentrated via vacuo
Sources & evidence
- ORD record
- ord-9bd6cd05666a4e718f9834dcbefc00f3
- Source dataset
- uspto-grants-2009_04
- Patent number
- US07524873B2
Reaction notes
Loading…