tert-Butyl carbazate → tert-butyl N'-(quinolin-2-yl)methylene-hydrazinecarboxylate

HRID 2113478

Reaction equation

HRID 2113478 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=O.[NH:13]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[NH2:14]>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]=[N:14][NH:13][C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16]

Participants

4

Reactant 2

HCID 70091tert-Butyl carbazateHCID 796192-Quinolinecarboxaldehyde

Product 1

HCID 69201455tert-butyl N'-(quinolin-2-yl)methylene-hydrazinecarboxylate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 10.70 g 2-quinolinecarboxaldehyde and 9.00 g tert-butyl hydrazinecarboxylate in 200 ml of ethanol is refluxed for 2 h with stirring. Then the solution is evaporated to dryness and the residue is triturated with diisopropylether, separated off and dried at 50° C.

Workup

  1. customThen the solution is evaporated to dryness
  2. customthe residue is triturated with diisopropylether
  3. customseparated off
  4. customdried at 50° C.

Sources & evidence

ORD record
ord-1856801b857e41b486abb4661ce3c0d9
Source dataset
uspto-grants-2008_10
Patent number
US07432262B2

Linked notes

Loading…