HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-(3-Chloro-thiophen-2-yl)-3-(4-trifluoromethoxy-phenyl)-[1,2,4]oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-(Trifluoromethoxy)benzamidoxime | HCID 2733309 | — |
| Reactant | 3-Chlorothiophene-2-carbonyl chloride | HCID 2735824 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-(3-Chloro-thiophen-2-yl)-3-(4-trifluoromethoxy-phenyl)-[1,2,4]oxadiazole | HCID 10132392 | 75% |
Reaction Steps
A solution of 3-chloro-thiophene-2-carbonyl chloride (72.4 mg, 0.4 mmol) and 4-trifluoromethoxybenzamidoxime (88 mg, 0.4 mmol) in dioxane:pyridine (11 mL, 10:1) was refluxed for 10 h and cooled to room temperature. To the stirred solution was added 20 mL of water to produce precipitates. The solid was collected by filtration and washed with dioxane:water (1:3), and dried to yield 103 mg (75%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07435750B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-5526b1a6d095463c83966224161e3a1f |
| Source note | uspto-grants-2008_10 |