Ethyl [(phenoxycarbonyl)oxy]acetate → 2-(Ethyloxy)-2-oxoethyl 4-{2-[(4-bromophenyl)oxy]ethyl}-1-piperidinecarboxylate

HRID 2116605

Reaction equation

HRID 2116605 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.C1([O:23][C:24]([O:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])=O)C=CC=CC=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][CH2:9][CH2:10][CH:11]2[CH2:12][CH2:13][N:14]([C:24]([O:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29])=[O:23])[CH2:15][CH2:16]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetateHCID 568302784-{2-[(4-Bromophenyl)oxy]ethyl}-piperidine

Product 1

HCID 674150252-(Ethyloxy)-2-oxoethyl 4-{2-[(4-bromophenyl)oxy]ethyl}-1-piperidinecarboxylateYield 54.6%

Procedure

The procedure described in Example 4.3. is repeated. Starting from 1.76 g (6.19 mmol) of 4-{2-[(4 bromophenyl)oxy]ethyl} prepared in Step 9.2., and 1.39 g (6.19 mmol) of ethyl {[(phenyloxy)carbonyl]oxy}-acetate, prepared in accordance with Example 1.1., gives 1.4 g of product in oil form.

Sources & evidence

ORD record
ord-9976c28eadc740bbb9727621bad4504a
Source dataset
uspto-grants-2008_10
Patent number
US07439257B2

Linked notes

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