2-Chloro-3-(trifluoromethyl)pyridine → 2-(4-(4,5-Bis-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-5,6-dihydropyridin-1(2H)-yl)-3-(trifluoromethyl)pyridine

HRID 2116909

Reaction equation

HRID 2116909 reaction equation
[F:1][C:2]([F:31])([F:30])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([C:24]3[CH2:25][CH2:26][NH:27][CH2:28][CH:29]=3)[NH:12][C:13]=2[C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[CH:5][CH:4]=1.Cl[C:33]1[C:38]([C:39]([F:42])([F:41])[F:40])=[CH:37][CH:36]=[CH:35][N:34]=1>>[F:31][C:2]([F:1])([F:30])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[C:11]([C:24]3[CH2:25][CH2:26][N:27]([C:33]4[C:38]([C:39]([F:42])([F:41])[F:40])=[CH:37][CH:36]=[CH:35][N:34]=4)[CH2:28][CH:29]=3)[NH:12][C:13]=2[C:14]2[CH:15]=[CH:16][C:17]([C:20]([F:22])([F:23])[F:21])=[CH:18][CH:19]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 586258184-[4,5-Bis-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-1,2,3,6-tetrahydropyridine

Product 1

HCID 116642732-(4-(4,5-Bis-(4-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)-5,6-dihydropyridin-1(2H)-yl)-3-(trifluoromethyl)pyridine

Procedure

4-[4,5-Bis-(4-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-1,2,3,6-tetrahydropyridine from step (b) above reacted with 2-chloro-3-trifluoromethyl-pyridine (352 mg, 1.95 mmol, TCI America) under the condition of Example 22(d) to give the title compound as a light-yellow solid. MS (ESI, positive ion) m/z: 583 (M+1).

Sources & evidence

ORD record
ord-7a47e49fe73340bfa085bb8b3b2f028d
Source dataset
uspto-grants-2008_10
Patent number
US07439360B2

Linked notes

Loading…