Diethyl (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonate → HCID 9813750, compound
Reaction equation
C([O:3][C:4](=[O:22])[CH:5]([CH2:11][C:12]1[C:13]([CH2:20][OH:21])=[C:14]([OH:19])[C:15]([CH3:18])=[N:16][CH:17]=1)[C:6]([O:8]CC)=[O:7])C>[OH-].[Na+].C(O)C>[CH3:18][C:15]1[C:14]([OH:19])=[C:13]([CH2:20][OH:21])[C:12]([CH2:11][CH:5]([C:6]([OH:8])=[O:7])[C:4]([OH:22])=[O:3])=[CH:17][N:16]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
The product of Example 25, of structure XXIX (620 mg, 2.0 mmol) was dissolved in aqueous NaOH (2 M, 4 mL) and stirred at room temperature for 1 hour. The reaction was quenched by adding 6 N HCl to give pH 4 to 5. The solution was diluted with 95% ethanol, separated from the precipitated salts and evaporated to give 540 mg.