7-Chloro-1,2,3,4-tetrahydroisoquinoline → (7-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

HRID 2117417

Reaction equation

HRID 2117417 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][NH:8][CH2:9]2)=[CH:4][CH:3]=1.[CH:12]([O:15][C:16]1[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][C:17]=1[C:18](O)=[O:19])([CH3:14])[CH3:13]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:18]([C:17]3[CH:21]=[C:22]([S:25]([CH3:28])(=[O:27])=[O:26])[CH:23]=[CH:24][C:16]=3[O:15][CH:12]([CH3:14])[CH3:13])=[O:19])[CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 125950697-Chloro-1,2,3,4-tetrahydroisoquinolineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 11517075(7-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Procedure

Prepared in analogy to example 1.1 from 7-chloro-1,2,3,4-tetrahydro-isoquinoline (CA [82771-60-6]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1).

Sources & evidence

ORD record
ord-75efa1a58376451eb0f8a5b8dc43c349
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Linked notes

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