5,7-Dichloro-1,2,3,4-tetrahydroisoquinoline → HCID 57445264, compound

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2.[CH:13]([O:16][C:17]1[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][C:18]=1[C:19](O)=[O:20])([CH3:15])[CH3:14]>>[Cl:1][C:2]1[CH:11]=[C:10]([Cl:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([C:19]([C:18]1[CH:22]=[C:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:24]=[CH:25][C:17]=1[O:16][CH:13]([CH3:15])[CH3:14])=[O:20])[CH2:7]2

Participants

Reactant 2

HCID 125950735,7-Dichloro-1,2,3,4-tetrahydroisoquinoline

HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 57445264HCID 57445264, compound

Procedure

Prepared in analogy to example 1.1 from 5,7-dichloro-1,2,3,4-tetrahydro-isoquinoline (CA [89315-56-0]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1).

Sources & evidence

ORD record: ord-6e810424eec64f46b71cca30decad8a6
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07442710B2

Reaction notes

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