Methanol → N-[5-[2-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-1-hydroxypropyl]-2-hydroxyphenyl]methanesulfonamide

HRID 211759

Reaction equation

HRID 211759 reaction equation
[BH3:7].[CH3:41][OH:42].[F:25][C:26]([c:27]1[cH:28][c:29]([CH:30]=[O:31])[cH:32][c:33]([C:35]([F:36])([F:37])[F:38])[cH:34]1)([F:39])[F:40].[NH2:8][CH:9]([CH:10]([OH:11])[c:12]1[cH:13][cH:14][c:15]([OH:23])[c:16]([NH:18][S:19](=[O:20])(=[O:21])[CH3:22])[cH:17]1)[CH3:24].[n:1]1[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[NH:8]([CH:9]([CH:10]([OH:11])[c:12]1[cH:13][cH:14][c:15]([OH:23])[c:16]([NH:18][S:19](=[O:20])(=[O:21])[CH3:22])[cH:17]1)[CH3:24])[CH2:30][c:29]1[cH:28][c:27]([C:26]([F:25])([F:39])[F:40])[cH:34][c:33]([C:35]([F:36])([F:37])[F:38])[cH:32]1

Participants

6

Reactant 5

HCID 887MethanolHCID 1049PyridineHCID 6331BoraneHCID 1362473,5-Bis(trifluoromethyl)benzaldehydeHCID 67814501N-[5-(2-amino-1-hydroxypropyl)-2-hydroxyphenyl]methanesulfonamide

Product 1

HCID 75058899N-[5-[2-[[3,5-bis(trifluoromethyl)phenyl]methylamino]-1-hydroxypropyl]-2-hydroxyphenyl]methanesulfonamide

Sources & evidence

ORD record
ord-9c0060944a6d446197f9e91287adcdf6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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