Acetic Anhydride → HCID 14543798, compound
Reaction equation
[C:1]([O:4][CH:5]1[NH:8][C:7](=[O:9])[CH:6]1[CH2:10][CH2:11][CH3:12])(=[O:3])[CH3:2].[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([N:8]1[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH:6]([CH2:10][CH2:11][CH3:12])[C:7]1=[O:9])(=[O:15])[CH3:14]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 56 mg (0.33 mM) 4-acetoxy-3-propylazetidin-2-one, 1 ml acetic anhydride and 1 ml pyridine was stirred at 100° in a sealed tube for 24 hours. After concentrating in vacuo the residue was chromatographed on silica gel in hexane/ethyl acetate, to yield 16 mg (23%) 1-acetyl-4-acetoxy-3-n-propyl-azetidine-2-one.
Workup
- concentrationAfter concentrating in vacuo the residue
- customwas chromatographed on silica gel in hexane/ethyl acetate
Sources & evidence
- ORD record
- ord-8986255b872b4d0fa95be56f23064912
- Source dataset
- uspto-grants-1987_07
- Patent number
- US04680391
Reaction notes
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