HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropylamine → 2-(2,4-Dichloro-benzoyl)-3-cyclopropylaminoacrylonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | 2-(2,4-Dichloro-benzoyl)-3-methoxyacrylonitrile | HCID 53739244 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2,4-Dichloro-benzoyl)-3-cyclopropylaminoacrylonitrile | HCID 67944888 | 86.9% |
Reaction Steps
2.5 g of cyclopropylamine are added dropwise to a solution of 11 g of 2-(2,4-dichloro-benzoyl)-3-methoxyacrylonitrile in 40 ml of ethanol, while cooling with ice and stirring. The mixture is stirred at room temperature for 25 minutes and then heated at the boiling point for 15 minutes. The solvent is removed in vacuo and the residue is recrystallized from ethanol/light petrol. 10.5 g of 2-(2,4-dichloro-benzoyl)-3-cyclopropylaminoacrylonitrile of melting point 93°-94° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680401 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-0bbe747a015f421e9260b2046be396e5 |
| Source note | uspto-grants-1987_07 |