4-[(4-fluorophenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid → 9H-Pyrazolo[4,3-b]quinolin-9-one, 5-ethyl-1,4-dihydro-1-methyl-

Reaction equation

[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:11]=[N:12][N:13]([CH3:18])[C:14]=1[C:15]([OH:17])=O)[CH3:2].FC1C=CC(NC2C=NN(C)C=2C(O)=O)=CC=1>>[CH2:1]([C:3]1[C:4]2[NH:9][C:10]3[CH:11]=[N:12][N:13]([CH3:18])[C:14]=3[C:15](=[O:17])[C:5]=2[CH:6]=[CH:7][CH:8]=1)[CH3:2]

Participants

Reactant 2

HCID 129856934-[(4-fluorophenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid

HCID 129857064-[(2-ethylphenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid

Product 1

HCID 129857079H-Pyrazolo[4,3-b]quinolin-9-one, 5-ethyl-1,4-dihydro-1-methyl-

Procedure

The title compound was prepared according to the procedure of step 2 in EXAMPLE 1 using 4-[(2-ethylphenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid (EXAMPLE 7, step 1), instead of 4-[(4-fluorophenyl)amino]-1-methyl-1H-pyrazole-5-carboxylic acid.

Sources & evidence

ORD record: ord-8a559dc9e4d24f2c977a3694da13e018
Source dataset: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06686373B2

Reaction notes

Loading…