Diazomethane → 2,4,5-Trimethylisoxazol-3(2H)-one
Reaction equation
[OH:1][C:2]1[C:6]([CH3:7])=[C:5]([CH3:8])[O:4][N:3]=1.[N+](=[CH2:11])=[N-]>CCOCC>[CH3:11][N:3]1[C:2](=[O:1])[C:6]([CH3:7])=[C:5]([CH3:8])[O:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 3-hydroxy-4,5-dimethylisoxazole (7 g, 62 mmol) in ether (50 mL) was added diazomethane until a persistent yellow colour was obtained. The reaction was stirred for another 30 min at room temperature. The ether was evaporated off and the residue purified by column chromatography on silica gel using ether as eluent. 4 g of the desired material was obtained.
Workup
- customwas obtained
- customThe ether was evaporated off
- customthe residue purified by column chromatography on silica gel
Sources & evidence
- ORD record
- ord-106c5a73609441c0bb0ac152402a1ea8
- Source dataset
- uspto-grants-2004_02
- Patent number
- US06693111B1
Reaction notes
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