Dimethyl Sulfoxide → 2-(1-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-4-morpholinopyrido[3,2-d]pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)acetonitrile

HRID 212207

Reaction equation

HRID 212207 reaction equation
[CH3:41][S:42]([CH3:43])=[O:44].[Cl:1][c:2]1[n:3][c:4]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([C:19]([CH3:20])([CH3:21])[OH:22])[CH2:17][CH2:18]1)[n:11]2.[nH:29]1[c:30]([CH2:38][C:39]#[N:40])[n:31][c:32]2[c:33]1[cH:34][cH:35][cH:36][cH:37]2>>[c:2]1(-[n:29]2[c:30]([CH2:38][C:39]#[N:40])[n:31][c:32]3[c:33]2[cH:34][cH:35][cH:36][cH:37]3)[n:3][c:4]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[c:5]2[c:6]([n:7]1)[cH:8][cH:9][c:10]([CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([C:19]([CH3:20])([CH3:21])[OH:22])[CH2:17][CH2:18]1)[n:11]2

Participants

4

Reactant 3

HCID 679Dimethyl SulfoxideHCID 204551H-Benzimidazole-2-acetonitrileHCID 584049702-(1-((2-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-6-yl)methyl)piperidin-4-yl)propan-2-ol

Product 1

HCID 533791312-(1-(6-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-4-morpholinopyrido[3,2-d]pyrimidin-2-yl)-1H-benzo[d]imidazol-2-yl)acetonitrile

Sources & evidence

ORD record
ord-08565b6215154f909bd7ce52b6e49a06
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

Loading…