HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(4-Chlorophenyl)pyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-(4-Chlorophenyl)-3-(dimethylamino)acrylaldehyde | HCID 3448972 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(4-Chlorophenyl)pyrimidin-2(1H)-one | HCID 13605538 | 29.7% |
Reaction Steps
A mixture of 2-(4-chlorophenyl)dimethylaminopropenal (Example 145a) (5.13 g), urea (2.4 g), concentrated HCl (10 ml), water (4 ml) and ethanol (150 ml) was refluxed for 4 hours. After cooling to room temperature concentrated ammonium chloride was added until the pH was 7. The resulting yellow solid was filtered off and dried yielding 1.5 g of 5-(4-chlorophenyl)-2-pyrimidinone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728698 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-682083a1fe1b4917a49c1da58af0cb59 |
| Source note | uspto-grants-1998_03 |