Benzene → 6-Cyano-1-(5-isothiazolyl)-3,4-dihydronaphthalene

Reaction equation

[C:1](#[N:2])[c:3]1[cH:4][c:5]2[c:10]([cH:11][cH:12]1)[C:9]([c:13]1[cH:14][cH:15][n:16][s:17]1)([OH:18])[CH2:8][CH2:7][CH2:6]2.[CH2:23]1[NH:24][CH2:25][CH2:26][O:27][CH2:28]1.[S:19]([Cl:20])([Cl:21])=[O:22].[cH:29]1[cH:30][cH:31][cH:32][cH:33][cH:34]1>>[C:1](#[N:2])[c:3]1[cH:4][c:5]2[c:10]([cH:11][cH:12]1)[C:9]([c:13]1[cH:14][cH:15][n:16][s:17]1)=[CH:8][CH2:7][CH2:6]2

Participants

Reactant 4

HCID 241Benzene

HCID 8083Morpholine

HCID 24386Thionyl Chloride

HCID 189490166-Cyano-1-hydroxy-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

Product 1

HCID 233653536-Cyano-1-(5-isothiazolyl)-3,4-dihydronaphthalene

Sources & evidence

ORD record: ord-2585973b371240b0a1eae2e65f2ab363
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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