Ethanol → Methyl 4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([C:21](=[O:22])[O:23][CH3:24])[CH:11]([c:13]2[c:14]([F:20])[cH:15][c:16]([F:19])[cH:17][cH:18]2)[CH2:12]1.[CH3:25][CH2:26][OH:27].[OH-:28].[OH-:30].[Pd+2:29]>>[NH:8]1[CH2:9][CH:10]([C:21](=[O:22])[O:23][CH3:24])[CH:11]([c:13]2[c:14]([F:20])[cH:15][c:16]([F:19])[cH:17][cH:18]2)[CH2:12]1

Participants

Reactant 4

HCID 702Ethanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 72524844Methyl 1-benzyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate

Product 1

HCID 67211849Methyl 4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate

Sources & evidence

ORD record: ord-9c68eb4c803548d682dab1997be715ca
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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