Aniline → 7-Benzyl-5,6,7,8-tetrahydro-N-phenylpyrido[3,4-d]pyrimidin-4-amine

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][c:10]2[n:11][cH:12][n:13][c:14]([Cl:18])[c:15]2[CH2:16][CH2:17]1.[CH3:26][C:27]#[N:28].[NH2:19][c:20]1[cH:21][cH:22][cH:23][cH:24][cH:25]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][c:10]2[n:11][cH:12][n:13][c:14]([NH:19][c:20]3[cH:21][cH:22][cH:23][cH:24][cH:25]3)[c:15]2[CH2:16][CH2:17]1

Participants

Reactant 3

HCID 6115Aniline

HCID 6342Acetonitrile

HCID 219588387-Benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Product 1

HCID 597717937-Benzyl-5,6,7,8-tetrahydro-N-phenylpyrido[3,4-d]pyrimidin-4-amine

Sources & evidence

ORD record: ord-f43266d50aed4d2398dde7b6afeb18b4
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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