Ammonia → 1-(3-Aminomethyl-2-fluorobenzyl)-3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one

HRID 2133859Notes

Reaction equation

HRID 2133859 reaction equation
[Br:1][c:2]1[c:3](=[O:28])[n:4]([CH2:18][c:19]2[c:20]([F:27])[c:21]([CH2:25][Br:26])[cH:22][cH:23][cH:24]2)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]1.[CH3:30][OH:31].[NH3:29]>>[Br:1][c:2]1[c:3](=[O:28])[n:4]([CH2:18][c:19]2[c:20]([F:27])[c:21]([CH2:25][NH2:29])[cH:22][cH:23][cH:24]2)[cH:5][cH:6][c:7]1[O:8][CH2:9][c:10]1[c:11]([F:17])[cH:12][c:13]([F:16])[cH:14][cH:15]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 887MethanolHCID 220504863-bromo-1-(3-bromomethyl-2-fluorobenzyl)-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one

Product 1

HCID 114196271-(3-Aminomethyl-2-fluorobenzyl)-3-bromo-4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one

Sources & evidence

ORD record
ord-1c8e383401d1492591826ae52090c47a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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