Methyl iodide → 4-Methoxymethyl-1-methyl-pyridinium iodide
Reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1.[CH3:10][I:11]>C(#N)C>[I-:11].[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][N+:7]([CH3:10])=[CH:6][CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 4.8 g (0.039 mol) of 4-methoxymethyl-pyridine in 25 ml of acetonitrile is mixed with 6.6 g (0.047 mol) of methyl iodide and stirred for 5 hours at ambient temperature. Then the partially precipitated quaternary salt is precipitated by the addition of ethyl acetate. 9.1 g (88% of theory) of 4-methoxymethyl-1-methyl-pyridinium iodide are obtained, m.p. 105°-108° C.
Workup
- customThen the partially precipitated quaternary salt is precipitated by the addition of ethyl acetate
Sources & evidence
- ORD record
- ord-5b2866a54c594fe0988446603115cc4e
- Source dataset
- uspto-grants-1995_06
- Patent number
- US05422353
Reaction notes
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