4-Methyloxybenzyl chloride → 2-{4-[4-(2,6-difluorophenyl)-2-hydroxybutyl]piperazinyl}-N-(2,6-dimethylphenyl)acetamide

HRID 2141636Notes

Reaction equation

HRID 2141636 reaction equation
[CH3:1][c:2]1[c:3]([NH:9][C:10]([CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH:19]([CH2:20][CH2:21][c:22]3[cH:23][cH:24][c:25]([O:26][CH3:27])[cH:28][cH:29]3)[OH:30])[CH2:16][CH2:17]2)=[O:31])[c:4]([CH3:8])[cH:5][cH:6][cH:7]1.[CH3:42][O:43][c:44]1[cH:45][cH:46][c:47]([CH2:48][Cl:49])[cH:50][cH:51]1.[F:32][c:33]1[c:34]([CH2:35][Cl:36])[c:37]([F:41])[cH:38][cH:39][cH:40]1>>[CH3:1][c:2]1[c:3]([NH:9][C:10]([CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH2:18][CH:19]([CH2:20][CH2:35][c:34]3[c:33]([F:32])[cH:40][cH:39][cH:38][c:37]3[F:41])[OH:30])[CH2:16][CH2:17]2)=[O:31])[c:4]([CH3:8])[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 699934-Methyloxybenzyl chlorideHCID 5815702,6-Difluorobenzyl chlorideHCID 12052937N-(2,6-dimethylphenyl)-2-{4-[4-(4-methoxyphenyl)-2-hydroxybutyl]piperazinyl}acetamide

Product 1

HCID 101135982-{4-[4-(2,6-difluorophenyl)-2-hydroxybutyl]piperazinyl}-N-(2,6-dimethylphenyl)acetamide

Sources & evidence

ORD record
ord-7f1b4a24d711490a8e6d16ddeeb4eff1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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