Acetate → 3-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester

Reaction equation

[Br:21][c:22]1[s:23][cH:24][cH:25][n:26]1.[C:28]([O-:29])(=[O:30])[CH3:31].[C:33]([O-:34])(=[O:35])[CH3:36].[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][CH2:6][c:7]1[n:8][n:9][c:10]([Cl:19])[c:11]2[cH:12][c:13]([O:17][CH3:18])[cH:14][cH:15][c:16]12)=[O:20].[Pd+2:32].[Zn:27]>>[CH2:1]([CH3:2])[O:3][C:4]([CH2:5][CH2:6][c:7]1[n:8][n:9][c:10](-[c:22]2[s:23][cH:24][cH:25][n:26]2)[c:11]2[cH:12][c:13]([O:17][CH3:18])[cH:14][cH:15][c:16]12)=[O:20]

Participants

Reactant 5

HCID 175Acetate2×

HCID 23994Zinc

HCID 764302-Bromothiazole

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 867576483-(4-Chloro-6-methoxy-phthalazin-1-yl)-propionic acid ethyl ester

Product 1

HCID 540412213-(6-Methoxy-4-thiazol-2-yl-phthalazin-1-yl)-propionic acid ethyl ester

Sources & evidence

ORD record: ord-c25cc429d43c41ba9ffeb84882041f34
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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