3-Bromo-4-methylbenzonitrile → 5-(5-Cyano-2-methylphenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide

HRID 2154672

Reaction equation

HRID 2154672 reaction equation
[Br:25][c:26]1[c:27]([CH3:34])[cH:28][cH:29][c:30]([C:32]#[N:33])[cH:31]1.[CH:1]1([NH:4][C:5](=[O:6])[c:7]2[cH:8][cH:9][c:10]([CH3:24])[c:11]([NH:13][C:14](=[O:15])[c:16]3[cH:17][cH:18][c:19]([B:21]([OH:22])[OH:23])[s:20]3)[cH:12]2)[CH2:2][CH2:3]1>>[CH:1]1([NH:4][C:5](=[O:6])[c:7]2[cH:8][cH:9][c:10]([CH3:24])[c:11]([NH:13][C:14](=[O:15])[c:16]3[cH:17][cH:18][c:19](-[c:26]4[c:27]([CH3:34])[cH:28][cH:29][c:30]([C:32]#[N:33])[cH:31]4)[s:20]3)[cH:12]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 140048403-Bromo-4-methylbenzonitrileHCID 597615035-(5-(Cyclopropylcarbamoyl)-2-methylphenylcarbamoyl)thiophen-2-ylboronic acid

Product 1

HCID 671490115-(5-Cyano-2-methylphenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-a917babfb7914c91b3fb8e7e2077e9fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Linked notes

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