Nitric Acid → HCID 178418402, compound

HRID 2155

Reaction equation

HRID 2155 reaction equation
[N:1]#[C:2][NH2:3].[F:4][C:5]([F:14])([F:13])[C:6]1[CH:7]=[C:8]([CH:10]=[CH:11][CH:12]=1)[NH2:9].[N+:15]([O-:18])([OH:17])=[O:16]>C(O)C>[N+:15]([O-:18])([OH:17])=[O:16].[F:4][C:5]([F:13])([F:14])[C:6]1[CH:7]=[C:8]([NH:9][C:2]([NH2:3])=[NH:1])[CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 73753-(Trifluoromethyl)anilineHCID 9864Cyanamide

Product 1

HCID 178418402HCID 178418402, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6.3 g (150 mmol) of cyanamide (50% in water) are added to a suspension of 16.1 g (100 mmol) of 3-trifluoromethyl-aniline in 35 ml of ethanol. 7.0 ml of nitric acid (65%, 0.1 mol) are then added to the brown solution and the reaction mixture is heated for 20 h under RF. It is then cooled to 0° and filtered, and the material retained on the filter is washed with ethanol and dried at 60° under HV to give 3-trifluoromethyl-phenylguanidine nitrate; 1H-NMR (dimethyl sulfoxide): 7.6 (7H,m), 9.9 (1H,br,s).

Workup

  1. temperaturethe reaction mixture is heated for 20 h under RF
  2. temperatureIt is then cooled to 0°
  3. filtrationfiltered
  4. washis washed with ethanol
  5. customdried at 60° under HV

Sources & evidence

ORD record
ord-dd9f79aff70f4e008da6da583aa08a55
Source dataset
uspto-grants-1998_03
Patent number
US05728708

Linked notes

Loading…