Methanol → [1-(6'-Oxo-1',6'-dihydro-[3,3']bipyridinyl-6-yl)-cyclopropyl]-carbamic acid tert-butyl ester

Reaction equation

[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1([c:11]2[cH:12][cH:13][c:14](-[c:17]3[cH:18][n:19][c:20]([O:23][CH2:24][c:25]4[cH:26][cH:27][cH:28][cH:29][cH:30]4)[cH:21][cH:22]3)[cH:15][n:16]2)[CH2:9][CH2:10]1)=[O:31].[CH3:32][OH:33].[OH-:34].[OH-:35].[Pd+2:36]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([NH:7][C:8]1([c:11]2[cH:12][cH:13][c:14](-[c:17]3[cH:18][nH:19][c:20](=[O:23])[cH:21][cH:22]3)[cH:15][n:16]2)[CH2:9][CH2:10]1)=[O:31]

Participants

Reactant 4

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 67508567[1-(6'-Benzyloxy-[3,3']bipyridinyl-6-yl)-cyclopropyl]-carbamic acid tert-butyl ester

Product 1

HCID 68378938[1-(6'-Oxo-1',6'-dihydro-[3,3']bipyridinyl-6-yl)-cyclopropyl]-carbamic acid tert-butyl ester

Sources & evidence

ORD record: ord-e62847105a484920be088e728f924c5d
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (4/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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