Dichloromethane → Piperazine

Participants

Role	Name	HCID	Charge
Reactant	Dichloromethane	HCID 6344	—
Reactant	N-[3-chloro-phenyl]-4-[2-(1-piperazinyl)-4-pyridyl]-2-pyrimidineamine	HCID 21948237	—
Solvent	Methanol	HCID 887	—
Product	Piperazine	HCID 4837	—
Product	N-(3-chlorophenyl)-4-(2-chloropyridin-4-yl)pyrimidin-2-amine	HCID 9905031	—

Reaction Steps

Analogously to Example 1, there is obtained from 100 mg (0.31 mmol) of N-[3-chloro-phenyl]-4-(2-chloro-4-pyridyl)-2-pyrimidineamine and 500 mg (5.63 mmol) of piperazine, from the melt after chromatography (methylene chloride:methanol=95:5), N-[3-chloro-phenyl]-4-[2-(1-piperazinyl)-4-pyridyl]-2-pyrimidineamine;

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05728708
Source dataset	uspto-grants-1998_03
ORD ID	ord-8b8f64beacb447798a17fed01f8b02fc
Source note	uspto-grants-1998_03