Flurbiprofen Methyl Ester → Flurbiprofen
Reaction equation
C([O-])(=O)C.[Tl+3].C([O-])(=O)C.C([O-])(=O)C.[F:14][C:15]1[CH:20]=[C:19]([CH:21]([CH3:26])[C:22]([O:24]C)=[O:23])[CH:18]=[CH:17][C:16]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>C(O)(=O)C.CCCCCC>[F:14][C:15]1[CH:20]=[C:19]([CH:21]([CH3:26])[C:22]([OH:24])=[O:23])[CH:18]=[CH:17][C:16]=1[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Following the procedure of Example 2, the enol ether of the formula ##STR9## is reacted with thallium (III) acetate in an aqueous acetic acid/hexane mixture at 25° to 50° C. until methyl 2-(2-fluoro-4-biphenylyl)propionate is formed. This ester is isolated from the reaction mixture and hydrolyzed to 2-(2-fluoro-4-biphenylyl)propionic acid (generic name, flurbiprofen) by the described procedure.