Methyl isothiocyanate → N-methyl-N'-[2-((1,4-dimethyl-2-imidazolyl)methylthio)ethyl]thiourea
Reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[N:4]=[C:3]1[CH2:8][S:9][CH2:10][CH2:11][NH2:12].[CH3:13][N:14]=[C:15]=[S:16].C(OCC)(=O)C.C(O)C>C(O)C>[CH3:13][NH:14][C:15]([NH:12][CH2:11][CH2:10][S:9][CH2:8][C:3]1[N:2]([CH3:1])[CH:6]=[C:5]([CH3:7])[N:4]=1)=[S:16]Participants
5
Procedure
The reaction of 1,4-dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole (derived from the 6.2 g. dihydrobromide) with methyl isothiocyanate (1.34 g.) in ethanol (50 ml.) followed by chromatography on a column of silica gel with ethyl acetate-ethanol (9:1) an eluant gave N-methyl-N'-[2-((1,4-dimethyl-2-imidazolyl)methylthio)ethyl]thiourea (2.1 g.).
Sources & evidence
- ORD record
- ord-6b88958b561a476e95b7c3915b88d303
- Source dataset
- uspto-grants-1979_01
- Patent number
- US04137234
Reaction notes
Loading…