2-Amino-6-fluorobenzonitrile → 2-Amino-6-(methylamino)benzonitrile
Reaction equation
C([O-])(=O)C.[CH3:5][NH3+:6].[NH2:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12](F)[C:9]=1[C:10]#[N:11]>CNC=O>[NH2:7][C:8]1[CH:15]=[CH:14][CH:13]=[C:12]([NH:6][CH3:5])[C:9]=1[C:10]#[N:11]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The title compound is prepared by heating a 10 molar excess of methylammonium acetate and 2-amino-6-fluorobenzonitrile in N-methyl formamide at 140° C. for 5 hrs.
Sources & evidence
- ORD record
- ord-2da8c8d506164326b39e6dbd2c51eba6
- Source dataset
- uspto-grants-1985_03
- Patent number
- US04504660
Reaction notes
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