2-Chloro-5-(trifluoromethyl)pyridine → 2-Chloro-5-trichloromethylpyridine

HRID 2164453

Reaction equation

HRID 2164453 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](F)(F)F)=[CH:4][N:3]=1.[Cl-:12].[Al+3].[Cl-:14].[Cl-:15]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([Cl:15])([Cl:14])[Cl:12])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 923422-Chloro-5-(trifluoromethyl)pyridineHCID 6451240Aluminum(III) Chloride

Product 1

HCID 502932-Chloro-5-trichloromethylpyridine

Procedure

To 18.2 g of 2-chloro-5-trifluoromethyl pyridine, 20 g of aluminum chloride was added in 2 hours, and they were reacted under the predetermined reaction conditions as shown in Table 1. After the completion of the reaction, the reaction product was cooled and then introduced into ice water, and the oil layer was separated by liquid separation. The solvent was removed by distillation to obtain 2-chloro-5-trichloromethyl pyridine.

Workup

  1. customthey were reacted under the predetermined reaction conditions
  2. customAfter the completion of the reaction
  3. temperaturethe reaction product was cooled
  4. customthe oil layer was separated by liquid separation
  5. customThe solvent was removed by distillation

Sources & evidence

ORD record
ord-d59167c8efd6400badb46632f1a2389d
Source dataset
uspto-grants-1985_03
Patent number
US04504665

Linked notes

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