HCID 600389, compound → 5,8-Quinoxalinediol
Reaction equation
C[O:2][C:3]1[CH:12]=[CH:11][C:10]([O:13]C)=[C:9]2[C:4]=1[N:5]=[CH:6][CH:7]=[N:8]2.[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[OH:13][C:10]1[CH:11]=[CH:12][C:3]([OH:2])=[C:4]2[C:9]=1[N:8]=[CH:7][CH:6]=[N:5]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4 g (0.021 mol) of 5,8-dimethoxyquinoxaline was refluxed for 2 hours under heating in 50 ml of benzene together with 20 g of aluminum chloride. After allowing to cool to room temperature, the reaction solution was extracted with ethyl acetate, and the extract was dried and concentrated. Recrystallization of the residue from ethyl acetate gave 2.4 g (71%) of the end product. m.p. 234°-236° C.
Workup
- extractionthe reaction solution was extracted with ethyl acetate
- customthe extract was dried
- concentrationconcentrated
- customRecrystallization of the residue from ethyl acetate
Sources & evidence
- ORD record
- ord-0486eac9e00d4128b2775f52815d369e
- Source dataset
- uspto-grants-1985_03
- Patent number
- US04506001
Reaction notes
Loading…