(5-Methylpyrimidin-2-yl)methanol → 5-Methylpyrimidine-2-carbaldehyde
Reaction equation
[OH:1][CH2:2][C:3]1[N:8]=[CH:7][C:6]([CH3:9])=[CH:5][N:4]=1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[CH3:9][C:6]1[CH:5]=[N:4][C:3]([CH:2]=[O:1])=[N:8][CH:7]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
5-Methylpyrimidine-2-carboxaldehyde was prepared from 2-hydroxymethyl-5-methylpyrimidine by oxidation with excess manganese dioxide in boiling chloroform. The product was obtained as colourless crystals and was characterized by proton nuclear magnetic resonance spectroscopy. Proton nuclear magnetic resonance spectrum (CDCl3 ; δ in ppm): 2.44 (3H,s); 8.80 (2H,s); 10.06 (1H,s).
Workup
- customThe product was obtained as colourless crystals
Sources & evidence
- ORD record
- ord-2bdf565a13fb4b56a4133264da693543
- Source dataset
- uspto-grants-1990_07
- Patent number
- US04938793
Reaction notes
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