Citric Acid → Apomorphine

HRID 2167017

Reaction equation

HRID 2167017 reaction equation
C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.[CH3:13][N:14]1[C@@H:23]2[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([OH:32])[C:26]=3[C:21]3[C:22]2=[C:17]([CH:18]=[CH:19][CH:20]=3)[CH2:16][CH2:15]1.Cl.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[CH3:13][N:14]1[C@@H:23]2[CH2:24][C:25]3[CH:30]=[CH:29][C:28]([OH:31])=[C:27]([OH:32])[C:26]=3[C:21]3[C:22]2=[C:17]([CH:18]=[CH:19][CH:20]=3)[CH2:16][CH2:15]1

Participants

5

Reactant 3

HCID 311Citric AcidHCID 6251MannitolHCID 94104H-Dibenzo[de,g]quinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride (1:1), (6aR)-2×

Product 1

HCID 6005Apomorphine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Gelatin and mannitol are dispersed in purified water and mixed thoroughly (i.e., using a vacuum mixer) and homogenized. Apomorphine hydrochloride is added and the mixture was again homogenized to ensure complete dissolution of the apomorphine hydrochloride. The pH of the solution is adjusted to about 3.0 (i.e., by addition of a suitable acid, such as citric acid). The solution is then poured onto a sheet and dried in a heated oven.

Workup

  1. additionmixed thoroughly (i.e.
  2. stirringthe mixture was again homogenized
  3. additionby addition of a suitable acid
  4. additionThe solution is then poured onto a sheet
  5. customdried in a heated oven

Sources & evidence

ORD record
ord-209d9e9339364d4db7de1f3c96ee0a96
Source dataset
uspto-grants-2015_06
Patent number
US09044475B2

Linked notes

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