Methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate → 2-[(9R)-9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]acetonitrile
Reaction equation
[C:1]([CH:3]([C:8]1([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[CH2:13][C:12]2([CH2:18][CH2:17][CH2:16]C[CH2:14]2)[O:11][CH2:10][CH2:9]1)C(OC)=O)#[N:2].C(C(C1(C2C=CC(F)=CC=2)CC2(CCCC2)OCC1)C(OC)=O)#N.FC1C=CC(C2(CC#N)CC3(CCCCC3)OCC2)=CC=1>>[F:25][C:22]1[CH:21]=[CH:20][C:19]([C@@:8]2([CH2:3][C:1]#[N:2])[CH2:13][C:12]3([CH2:14][CH2:16][CH2:17][CH2:18]3)[O:11][CH2:10][CH2:9]2)=[CH:24][CH:23]=1Participants
4
Procedure
By the procedure described in the preparation of intermediate 10 substituting methyl 2-cyano-2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetate for methyl 2-cyano-2-[9-(4-fluorophenyl)-6-oxaspiro[4.5]decan-9-yl]acetate, 2-[4-(4-fluorophenyl)-1-oxaspiro[5.5]undecan-4-yl]acetonitrile was prepared (m/z 287.2 [M+H]+ observed).