Ethanol hydrochloride → HCID 136351074, compound

Reaction equation

[OH:1][C:2]1[C:9]([O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:18][CH2:19][OH:20].[ClH:21]>>[ClH:21].[OH:1][C:2]1[C:9]([O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4](=[NH:5])[O:20][CH2:19][CH3:18]

Participants

Reactant 2

HCID 21887872Ethanol hydrochloride

HCID 58506482HCID 58506482, compound

Product 1

HCID 136351074HCID 136351074, compound

Procedure

A solution of 2-hydroxy-3-(2-(2-methoxyethoxy)ethoxy)benzonitrile (6 g) in EtOH/HCl (g) (150 mL) was heated to 40° C. overnight in a sealed tube. The solvent was evaporated under vacuum and the residue (7 g, crude) was used for the next step without further purification.

Workup

customThe solvent was evaporated under vacuum
customthe residue (7 g, crude) was used for the next step without further purification

Sources & evidence

ORD record: ord-f4064b5af8634a8d83c77c9e1cbd28a0
Source dataset: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09045440B2

Reaction notes

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