Chloroacetaldehyde → HCID 90427811, compound
Reaction equation
[NH2:1][C:2]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[C:3]=1[C:4]#[N:5].Cl[CH2:13][CH:14]=O>O>[CH3:10][C:8]1[N:9]2[CH:13]=[CH:14][N:1]=[C:2]2[C:3]([C:4]#[N:5])=[C:6]([CH3:11])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80 oC for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
Workup
- temperaturewas heated at 80 oC for 16 h
- customOn completion, it was quenched by 1N NaOH till pH 8
- customSolid precipitated
- filtrationwas filtered
- customvacuum dried
Sources & evidence
- ORD record
- ord-44a3673fc57c4ef3b2740055c7d326b1
- Source dataset
- uspto-grants-2015_06
- Patent number
- US09045477B2
Reaction notes
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